By Ben Goldacre
Bad Science hilariously uncovered the tips that quacks and reporters use to distort technology, turning into a 400,000 reproduction bestseller. Now Ben Goldacre places the $600bn international pharmaceutical lower than the microscope. What he unearths is an interesting, terrifying mess.
Doctors and sufferers want solid medical facts to make knowledgeable judgements. yet as a substitute, businesses run undesirable trials all alone medicines, which distort and exaggerate the advantages through layout. whilst those trials produce unflattering effects, the information is just buried. All of this can be completely felony. in truth, even executive regulators withhold very important facts from the folk who desire it so much. medical professionals and sufferer teams have stood by way of too, and did not shield us. as a substitute, they take cash and favours, in a global so fractured that medics and nurses are actually informed by way of the medicine undefined. sufferers are harmed in large numbers.
Ben Goldacre is Britain's best author at the technology in the back of medication, and 'Bad Pharma' is a transparent and witty assault, exhibiting precisely how the technological know-how has been distorted, how our platforms were damaged, and the way effortless it'd be to mend them.
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Additional resources for Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients
Steady State Free Precession (SSFP) in the sequence to improve the image contrast for coronary angiography [39;40]. It gives an excellent image contrast between blood and myocardium. SSFP is characterized by an alternating phase of excitation pulse combined MR Angiography and Development: Review of Clinical Applications 29 with the application of time balanced gradients for all gradient directions. SSFP provides high signal intensity for tissues with a high T2/T1 ratio (blood) independent of TR and flow artefacts.
Cardiac motion occurs in both systole and diastole, but is said to be minimal in middiastole (at diastasis). Cardiac motion correction is therefore usually achieved by timing the acquisition to the mid-diastolic phase of the cardiac cycle. There is considerable variation of motion patterns, motion ranges and motion velocities for coronary artery segments among individual patients. On average, the right coronary artery has greater movement and greater velocity as compared with the other coronary arteries, up to a factor of two for the proximal segments.
CE-MRA with gadofosveset, the only blood pool agent approved for use, has demonstrated improvements in sensitivity, specificity and accuracy compared with noncontrast time-of-flight MRA. However, the benefit of gadofosveset compared with other Gdcontrast agents has been more difficult to establish . Studies have shown that gadofosveset is superior to gadoterate meglumine (Dotarem®) and gadopentetate dimeglumine for MRA of the hand and whole body , respectively. 011) . 5. Magnetic resonance angiography of pulmonary vessels Selective visualization of the pulmonary arteries and veins in high spatial resolution has been the domain of conventional digital subtraction angiography.
Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients by Ben Goldacre