New PDF release: Atlas of Histopathology of the Cervix Uteri

By Dr. Gisela Dallenbach-Hellweg, Dr. Hemming Poulsen (auth.)

ISBN-10: 3662216442

ISBN-13: 9783662216446

ISBN-10: 3662216469

ISBN-13: 9783662216460

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Extra info for Atlas of Histopathology of the Cervix Uteri

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63. Microglandular hyperplasia of endocervix. H & E, higher magnification 47 Differential Diagnosis. Several features may help to differentiate a microglandular hyperplasia from an invasive carcinoma. The cells of micro glandular hyperplasia show less nuclear atypia; their cytoplasm contains mucin, not glycogen. In contrast to invasive adenocarcinoma, microglandular hyperplasia reacts negatively for CEA. Polyps of the Ectoand Endocervix (Figs. 65-67) Focal proliferation of the endocervical mucosa leads to polyp formation.

H & E 33 Fig. 44. Formation of sebaceous glands beneath ectocervical epithelium. H & E Fig. 45. Formation of sebaceous glands beneath ectocervical epithelium. H & E, higher magnification 34 Hormonally Induced Changes Estrogens and gestagens act as antagonists not only on the endometrium but also on the ecto- and endocervix (Dallenbach-Hellweg 1981; Table 1). Effects of Estrogen (Figs. 46-53) Parakeratosis and Hyperkeratosis of the Ectocervix Estrogens stimulate proliferation of the squamous epithelium of the ectocervix, resulting in a well-developed superficial cell layer often covered by a fairly thick layer of parakeratotic cells (Figs.

The glands may ramify (Fig. 56) or become crowded (Fig. 57). The production of mucin is reduced or absent and occurs irregularly from one gland to another (Fig. 58) or within the same gland (Figs. 59, 60). Cells with mucin and those without may lie together, In addition, the chemical composition of the mucus is often changed (Gaton et al. 1982). The reserve cells underneath the glandular and superficial epithelium may undergo hyperplasia to form several layers. That hyperplasia is stimulated by the gestagens.

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Atlas of Histopathology of the Cervix Uteri by Dr. Gisela Dallenbach-Hellweg, Dr. Hemming Poulsen (auth.)


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