Get Asymptomatic Atherosclerosis: Pathophysiology, Detection and PDF

By Morteza Naghavi (auth.), Morteza Naghavi (eds.)

ISBN-10: 1603271783

ISBN-13: 9781603271783

Despite fresh advances within the prognosis and therapy of symptomatic atherosclerosis, to be had conventional screening tools for early detection and remedy of asymptomatic coronary artery ailment are grossly inadequate and fail to spot the vast majority of sufferers sooner than the onset of a life-threatening occasion. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and remedy, Dr. Morteza Naghavi and top specialists from the Society for middle assault Prevention and Eradication (SHAPE) current a brand new paradigm for the screening and first prevention of asymptomatic atherosclerosis.

The textual content specializes in exact, but underutilized, measures of subclinical atherosclerosis, particularly coronary artery calcium scanning and carotid intima-media thickness dimension. The authors introduce a entire method of choosing the susceptible sufferers (asymptomatic members vulnerable to a close to destiny antagonistic event). extra chapters speak about destiny instructions in the direction of containing the epidemic of atherosclerotic heart problems utilizing cutting edge suggestions reminiscent of preemptive interventional remedies (bioabsorbable stents) for stabilization of weak atherosclerotic plaques, mass unconditional Polypill treatment for population-based danger relief, and finally vaccination recommendations to avoid the improvement of atherosclerosis.

Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and remedy is a must have for any heart specialist or basic care general practitioner who needs to perform glossy preventive cardiology and deal with the expanding variety of asymptomatic atherosclerotic patients.

• Outlines extra exact measures of threat (coronary artery calcium and carotid intima-media thickness) than conventional threat components (total ldl cholesterol, cholesterol, HDL cholesterol)

• provides new multipronged thoughts to assist within the early detection and therapy of excessive chance asymptomatic patients

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Download PDF by Morteza Naghavi (auth.), Morteza Naghavi (eds.): Asymptomatic Atherosclerosis: Pathophysiology, Detection and

Regardless of fresh advances within the prognosis and remedy of symptomatic atherosclerosis, on hand conventional screening tools for early detection and therapy of asymptomatic coronary artery ailment are grossly inadequate and fail to spot the vast majority of sufferers sooner than the onset of a life-threatening occasion.

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Extra info for Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment

Example text

Nucl Med Commun. 2001;22:747–753. 41. Ciavolella M, Tavolaro R, Taurino M, et al. Immunoscintigraphy of atherosclerotic uncomplicated lesions in vivo with a monoclonal antibody against D-dimers of insoluble fibrin. Atherosclerosis. 1999;143:171–175. 42. Tearney GJ, Yabushita H, Houser SL, et al. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation. 2003;107:113–119. 43. Krinsky GA, Freedberg R, Lee VS, et al. Innominate artery atheroma: a lesion seen with gadolinium-enhanced MR angiography and often missed by transesophageal echocardiography.

Plaque rupture is the most common type of plaque complication, accounting for ~70% of fatal acute myocardial infarctions and/or sudden coronary deaths (Fig. 2). Several retrospective autopsy series and a few cross-sectional clinical studies have suggested that thrombotic coronary death and acute coronary syndromes are caused by the plaque features and associated factors presented in Table 1 [5–7]. Most techniques for detecting and treating vulnerable plaque are devoted to ruptureprone plaque. This type of plaque has been termed a “thin-cap fibroatheroma” [8].

New studies are unraveling the role of the adventitia and periadventitial connective and adipose tissue in vulnerability of atherosclerotic plaques [92]. Further studies are needed to define the importance of these findings in the detection and treatment of vulnerable plaques. From Vulnerable Plaque to Vulnerable Patient25 25 Vulnerable (Thrombogenic) Blood Serum Markers of Atherosclerosis and Inflammation Serum markers may predict a patient’s risk of acute cardiovascular complications (Table 6).

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Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment by Morteza Naghavi (auth.), Morteza Naghavi (eds.)


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