New PDF release: Astrocytes and Epilepsy

By Jacqueline A. Hubbard, Devin K. Binder

ISBN-10: 0128024011

ISBN-13: 9780128024010

ISBN-10: 0128026243

ISBN-13: 9780128026243

Epilepsy is a devastating team of neurological problems characterised by way of periodic and unpredictable seizure job within the brain.  there's a severe want for brand spanking new medicinal drugs and techniques given than at the very least one-third of all epilepsy sufferers are usually not made freed from seizures by way of latest medicinal drugs and turn into "medically refractory".  a lot of epilepsy study has fascinated by neuronal healing goals, yet present antiepileptic medications usually reason critical cognitive, developmental, and behavioral unwanted side effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity.  in addition, many vital mobile and molecular adjustments take place in astrocytes in epileptic tissue in either people and animal types of epilepsy.  The aim of Astrocytes and Epilepsy is to comprehensively assessment intriguing findings linking adjustments in astrocytes to useful adjustments answerable for epilepsy for the 1st time in booklet format.  those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well characterize a major new healing goal within the regulate of epilepsy. 

Astrocytes and Epilepsy contains history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reports and animal types linking useful adjustments in astrocytes to epilepsy.  fantastically labelled diagrams are provided and proper figures from the literature are reproduced to explain key findings and ideas during this speedily rising field.  Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.

  • Presents the 1st accomplished e-book to synthesize old and up to date examine on astrocytes and epilepsy into one coherent volume
  • Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details capability healing pursuits, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

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Extra info for Astrocytes and Epilepsy

Sample text

Regarding microglia he stated: “Since it is of different ancestry and its characteristics differ from those of the nerve cells (first element) and the neuroglial astrocytes (second element) (containing astrocytes and oligodendrocytes), the microglia constitutes the true third element of the central nervous system” [87]. However, there was still much debate on the existence of oligodendroglia as a distinct CNS cell type, due in part to the difficulty involved in staining these cells. In fact, Cajal himself was unable to produce an effective and reproducible stain, leading him to dismiss these cells altogether as a true class of glial cells and to declare that the “third element” was made up exclusively of microglia.

13] Shepherd GM. Foundations of the neuron doctrine. New York: Oxford University Press; 1991. [14] Gjerstad L, Gilhus NE, Storstein A. A retrospective view on research in neuroscience in Norway. Acta Neurol Scand Suppl 2008;188:3–5. [15] Akert K. August Forel—cofounder of the neuron theory (1848–1931). Brain Pathol 1993;3(4):425–30. [16] Probst A, Langui D. The neuron theory: one of the main scientific achievements of the 19th century. Schweiz Rundsch Med Prax 1994;83(16):462–9. ASTROCYTES AND EPILEPSY REFERENCES 35 [17] Schwann T.

C R Soc Biol (Paris) 1910;68:1068–9. [66] Deleted in Review. [67] Achúcarro N. De l’évolution de la nevroglie et specialment de ses relations avec l’appareil vasculaire. Trav Lab Rech Biol Univ Madrid 1915;13:169–212. [68] Frommann C. Untersuchung über die Gewebsveränderungen bei der Multiplen Sklerose des Gehirns. Jena: Gustav Fischer; 1878. [69] Nissl F. Über einigen Beziehungen zur Nervenzellenerkrankungen und gliosen Erscheinungen bei verschiedene Psychosen. Arch Psychiatrie 1899;32:656–76.

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Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder

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