By Jacqueline A. Hubbard, Devin K. Binder
Epilepsy is a devastating team of neurological problems characterised by way of periodic and unpredictable seizure job within the brain. there's a severe want for brand spanking new medicinal drugs and techniques given than at the very least one-third of all epilepsy sufferers are usually not made freed from seizures by way of latest medicinal drugs and turn into "medically refractory". a lot of epilepsy study has fascinated by neuronal healing goals, yet present antiepileptic medications usually reason critical cognitive, developmental, and behavioral unwanted side effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity. in addition, many vital mobile and molecular adjustments take place in astrocytes in epileptic tissue in either people and animal types of epilepsy. The aim of Astrocytes and Epilepsy is to comprehensively assessment intriguing findings linking adjustments in astrocytes to useful adjustments answerable for epilepsy for the 1st time in booklet format. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well characterize a major new healing goal within the regulate of epilepsy.
Astrocytes and Epilepsy contains history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reports and animal types linking useful adjustments in astrocytes to epilepsy. fantastically labelled diagrams are provided and proper figures from the literature are reproduced to explain key findings and ideas during this speedily rising field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st accomplished e-book to synthesize old and up to date examine on astrocytes and epilepsy into one coherent volume
- Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
- Details capability healing pursuits, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Extra info for Astrocytes and Epilepsy
Regarding microglia he stated: “Since it is of different ancestry and its characteristics differ from those of the nerve cells (first element) and the neuroglial astrocytes (second element) (containing astrocytes and oligodendrocytes), the microglia constitutes the true third element of the central nervous system” . However, there was still much debate on the existence of oligodendroglia as a distinct CNS cell type, due in part to the difficulty involved in staining these cells. In fact, Cajal himself was unable to produce an effective and reproducible stain, leading him to dismiss these cells altogether as a true class of glial cells and to declare that the “third element” was made up exclusively of microglia.
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Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder