New PDF release: Astrocytes and Epilepsy

By Jacqueline A. Hubbard, Devin K. Binder

ISBN-10: 0128024011

ISBN-13: 9780128024010

ISBN-10: 0128026243

ISBN-13: 9780128026243

Epilepsy is a devastating team of neurological problems characterised by way of periodic and unpredictable seizure job within the brain.  there's a severe want for brand spanking new medicinal drugs and techniques given than at the very least one-third of all epilepsy sufferers are usually not made freed from seizures by way of latest medicinal drugs and turn into "medically refractory".  a lot of epilepsy study has fascinated by neuronal healing goals, yet present antiepileptic medications usually reason critical cognitive, developmental, and behavioral unwanted side effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity.  in addition, many vital mobile and molecular adjustments take place in astrocytes in epileptic tissue in either people and animal types of epilepsy.  The aim of Astrocytes and Epilepsy is to comprehensively assessment intriguing findings linking adjustments in astrocytes to useful adjustments answerable for epilepsy for the 1st time in booklet format.  those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may well characterize a major new healing goal within the regulate of epilepsy. 

Astrocytes and Epilepsy contains history explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reports and animal types linking useful adjustments in astrocytes to epilepsy.  fantastically labelled diagrams are provided and proper figures from the literature are reproduced to explain key findings and ideas during this speedily rising field.  Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.

  • Presents the 1st accomplished e-book to synthesize old and up to date examine on astrocytes and epilepsy into one coherent volume
  • Provides an exceptional source at the box of astrocyte biology and astrocyte-neuron interactions
  • Details capability healing pursuits, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Show description

Read Online or Download Astrocytes and Epilepsy PDF

Best physiology books

Get Human Anatomy PDF

Learn it, See it, grasp it! learn it- Ken Saladin explains the fabric in an attractive, but effective means. He places a top class at the phrases, and makes use of student-relevant analogies to encourage the reader. See it- utilizing the market-tested paintings from his A&P textual content, Saladin's illustrations are brilliant and practical.

Download e-book for kindle: Mathematical Foundations and Biomechanics of the Digestive by Roustem N. Miftahof, Hong Gil Nam

Mathematical modelling of physiological platforms grants to strengthen our figuring out of advanced organic phenomena and pathophysiology of illnesses. during this ebook, the authors undertake a mathematical method of signify and clarify the functioning of the gastrointestinal procedure. utilizing the mathematical foundations of skinny shell conception, the authors patiently and comprehensively consultant the reader in the course of the primary theoretical suggestions, through step by step derivations and mathematical routines, from simple idea to complicated physiological types.

Clinical Neurophysiology of Infancy, Childhood, and by Gregory L. Holmes MD, Solomon L. Moshé MD, H. Royden Jones PDF

This specific reference is exclusive in its particular devotion to the scientific neurophysiology of youngsters. Written by means of a stellar team of well-known specialists, it blends classical electrophysiological thoughts equivalent to EEG, EMG, and nerve conduction experiences with ultra-modern such a lot state-of-the-art tools, together with magnetic stimulation and magnetoencephalography.

Download e-book for kindle: Patch-Clamp Methods and Protocols by Marzia Martina, Stefano Taverna

Considering the fact that its inception, patch-clamp has persevered to be generally thought of the premiere solution to checklist ion channel job. Patch-Clamp equipment and Protocols, moment version, offers a entire number of new thoughts for the improvement of computerized, high-throughput screening structures for pharmacological assessment, using a number of patch-clamp configurations including novel molecular organic and imaging methodologies and greater stimulation protocols and perfusion platforms.

Extra info for Astrocytes and Epilepsy

Sample text

Regarding microglia he stated: “Since it is of different ancestry and its characteristics differ from those of the nerve cells (first element) and the neuroglial astrocytes (second element) (containing astrocytes and oligodendrocytes), the microglia constitutes the true third element of the central nervous system” [87]. However, there was still much debate on the existence of oligodendroglia as a distinct CNS cell type, due in part to the difficulty involved in staining these cells. In fact, Cajal himself was unable to produce an effective and reproducible stain, leading him to dismiss these cells altogether as a true class of glial cells and to declare that the “third element” was made up exclusively of microglia.

13] Shepherd GM. Foundations of the neuron doctrine. New York: Oxford University Press; 1991. [14] Gjerstad L, Gilhus NE, Storstein A. A retrospective view on research in neuroscience in Norway. Acta Neurol Scand Suppl 2008;188:3–5. [15] Akert K. August Forel—cofounder of the neuron theory (1848–1931). Brain Pathol 1993;3(4):425–30. [16] Probst A, Langui D. The neuron theory: one of the main scientific achievements of the 19th century. Schweiz Rundsch Med Prax 1994;83(16):462–9. ASTROCYTES AND EPILEPSY REFERENCES 35 [17] Schwann T.

C R Soc Biol (Paris) 1910;68:1068–9. [66] Deleted in Review. [67] Achúcarro N. De l’évolution de la nevroglie et specialment de ses relations avec l’appareil vasculaire. Trav Lab Rech Biol Univ Madrid 1915;13:169–212. [68] Frommann C. Untersuchung über die Gewebsveränderungen bei der Multiplen Sklerose des Gehirns. Jena: Gustav Fischer; 1878. [69] Nissl F. Über einigen Beziehungen zur Nervenzellenerkrankungen und gliosen Erscheinungen bei verschiedene Psychosen. Arch Psychiatrie 1899;32:656–76.

Download PDF sample

Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder


by Kenneth
4.0

Rated 4.26 of 5 – based on 41 votes