Download e-book for iPad: Anticancer Drug Toxicity: Prevention, Management, and by Hans-Peter Lipp

By Hans-Peter Lipp

ISBN-10: 0585375186

ISBN-13: 9780585375182

ISBN-10: 0824719301

ISBN-13: 9780824719302

Containing the newest findings at the toxicity of a variety of chemotherapeutic brokers, this up to date reference deals professional analyses at the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity ·explores healing drug tracking (TDM) as a style of maximizing the efficacy, and minimizing the hazards, of chemotherapy ·presents an unlimited quantity of scientific pharmacokinetic info on cytostatic medicinal drugs ·offers a accomplished type of toxicity styles linked to using cytotoxic medicines ·analyzes the pharmacokinetics of alkylating brokers, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and different cytotoxic brokers ·highlights the pharmacogenetics of 6-mercaptopurine and its medical value ·explicates toxicity relating to the lungs, kidneys, center, and gonads ·examines problems because of asparaginase arrangements ·reviews forms of secondary malignancy comparable to leukemias, ovarian melanoma, testicular melanoma, breast melanoma, secondary strong neoplasias, and Hodgkin's affliction ·clarifies the certainty of toxicity as a vital aspect in supportive administration of melanoma treatment ·and extra! An tremendously useful consultant for daily scientific perform, in addition to a resource of thought for additional learn within the box, Anticancer Drug Toxicity is a useful reference for scientific and scientific oncologists; clinic, business, and medical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and scientific tuition scholars in those disciplines.

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Additional info for Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics

Sample text

Mammals, birds, and fish all have representative species that are highly sensitive, as well as highly resistant, to dioxin-like adverse effects, especially chronic reproductive and developmental/endocrine effects. Aquatic food chain species (seals, dolphins, polar bears, fish-eating birds, and cold-water fish species) with high exposure potential through biomagnification are particularly vulnerable. Rice, O’Keefe, and Kubiak (Chapter 18) review the fate of these environmentally persistent compounds and their toxicity, which is complex and often chronic rather than acute.

S. federal government. Water quality standards consist of WQC in conjunction with plans for their implementation. 20 Prior to this time WQC were derived by assessing available acute and chronic aquatic toxicity data and selecting levels deemed to protect aquatic life based on the best available data and on good scientific judgment. 24 In some cases WQC were derived without chronic or partial life-cycle test data. Acute toxicity test results (LC50 — lethal concentration to 50% of the test organisms) were used to predict chronic no-effect levels by means of an application factor (AF).

167 8 Phytotoxicity Stephen J. Klaine, Michael A. Lewis, and Sandra L. 219 10 Using Biomonitoring Data for Stewardship of Natural Resources Robert P. Breckenridge, Marilynne Manguba, Patrick J. Anderson, and Timothy M. 233 11 Bioindicators of Contaminant Exposure and Effect in Aquatic and Terrestrial Monitoring Mark J. 257 CHAPTER 2 Aquatic Toxicology Test Methods William J. Adams and Carolyn D. 1 INTRODUCTION Aquatic toxicology is the study of the effects of toxic agents on aquatic organisms. This broad definition includes the study of toxic effects at the cellular, individual, population, and community levels.

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Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics by Hans-Peter Lipp

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