By Hans-Peter Lipp
Containing the newest findings at the toxicity of a variety of chemotherapeutic brokers, this up to date reference deals professional analyses at the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity ·explores healing drug tracking (TDM) as a style of maximizing the efficacy, and minimizing the hazards, of chemotherapy ·presents an unlimited quantity of scientific pharmacokinetic info on cytostatic medicinal drugs ·offers a accomplished type of toxicity styles linked to using cytotoxic medicines ·analyzes the pharmacokinetics of alkylating brokers, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and different cytotoxic brokers ·highlights the pharmacogenetics of 6-mercaptopurine and its medical value ·explicates toxicity relating to the lungs, kidneys, center, and gonads ·examines problems because of asparaginase arrangements ·reviews forms of secondary malignancy comparable to leukemias, ovarian melanoma, testicular melanoma, breast melanoma, secondary strong neoplasias, and Hodgkin's affliction ·clarifies the certainty of toxicity as a vital aspect in supportive administration of melanoma treatment ·and extra! An tremendously useful consultant for daily scientific perform, in addition to a resource of thought for additional learn within the box, Anticancer Drug Toxicity is a useful reference for scientific and scientific oncologists; clinic, business, and medical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and scientific tuition scholars in those disciplines.
Read Online or Download Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics PDF
Best toxicology books
An absolutely up-to-date and extended version of the bestselling advisor on toxicology and its useful applicationThe box of toxicology has grown vastly given that business Toxicology: protection and healthiness purposes within the office was once first released in 1985. And whereas the unique variation was once highly renowned between occupational overall healthiness execs, the time is ripe to handle poisonous brokers not just within the business atmosphere but additionally within the atmosphere at huge.
Because the ebook of the 1st variation of advent to Toxicology , toxicology has develop into a extra mature technology, the variety of undergraduate and postgraduate classes has elevated and hence the necessity for a frequently up to date introductory textual content has turn into extra urgent. This 3rd version caters for this desire in a transparent and easy-to-read type, featuring:* up to date details* correct toxicological examples that make stronger ideas* End-of-chapter essay questions* New and redrawn illustrations* word list of phrases* broadly revised bibliographyThe basic rules of absorption, distribution, metabolism and excretion are defined within the introductory chapters, as are the kinds of publicity and reaction.
This quantity provides a scientific and mathematically rigorous exposition of tools for learning linear partial differential equations. It makes a speciality of quantization of the corresponding gadgets (states, observables and canonical adjustments) within the section house. The quantization of all 3 forms of classical items is performed in a unified manner with using a distinct vital remodel.
Over the past decade, the foremost concentration of pollutant examine has shifted from formerly demonstrated contaminants to the rising contaminants of outrage. those rising contaminants will not be of contemporary beginning, yet their analytical quantification, publicity routes and pathways and consequent human future health and ecological results are actually changing into recognized.
- Biologic Markers in Immunotoxicology
- Chromatographic Methods in Clinical Chemistry and Toxicology
- Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases
- Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences)
- Biotechnology of fungal genes
Additional info for Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics
Mammals, birds, and fish all have representative species that are highly sensitive, as well as highly resistant, to dioxin-like adverse effects, especially chronic reproductive and developmental/endocrine effects. Aquatic food chain species (seals, dolphins, polar bears, fish-eating birds, and cold-water fish species) with high exposure potential through biomagnification are particularly vulnerable. Rice, O’Keefe, and Kubiak (Chapter 18) review the fate of these environmentally persistent compounds and their toxicity, which is complex and often chronic rather than acute.
S. federal government. Water quality standards consist of WQC in conjunction with plans for their implementation. 20 Prior to this time WQC were derived by assessing available acute and chronic aquatic toxicity data and selecting levels deemed to protect aquatic life based on the best available data and on good scientific judgment. 24 In some cases WQC were derived without chronic or partial life-cycle test data. Acute toxicity test results (LC50 — lethal concentration to 50% of the test organisms) were used to predict chronic no-effect levels by means of an application factor (AF).
167 8 Phytotoxicity Stephen J. Klaine, Michael A. Lewis, and Sandra L. 219 10 Using Biomonitoring Data for Stewardship of Natural Resources Robert P. Breckenridge, Marilynne Manguba, Patrick J. Anderson, and Timothy M. 233 11 Bioindicators of Contaminant Exposure and Effect in Aquatic and Terrestrial Monitoring Mark J. 257 CHAPTER 2 Aquatic Toxicology Test Methods William J. Adams and Carolyn D. 1 INTRODUCTION Aquatic toxicology is the study of the effects of toxic agents on aquatic organisms. This broad definition includes the study of toxic effects at the cellular, individual, population, and community levels.
Anticancer Drug Toxicity: Prevention, Management, and Clinical Pharmacokinetics by Hans-Peter Lipp