Download e-book for kindle: Alzheimer's Disease: Methods and Protocols (Methods in by N. M. Hooper

By N. M. Hooper

ISBN-10: 0585395071

ISBN-13: 9780585395074

ISBN-10: 0896037371

ISBN-13: 9780896037373

A panel of hugely expert investigators describe intimately their cutting-edge biochemical, telephone organic, and molecular organic options for learning the molecular foundation of Alzheimer's illness. those comfortably reproducible, step by step tools concentrate on paintings with the amyloid precursor protein and the amyloidogenic peptide A?, but in addition include-with the new id of presenilin proteins-techniques for settling on the constitution and organic functionality of those proteins. moreover, there are chapters overlaying the tau protein and its position in Alzheimer's sickness, in addition to an introductory dialogue of the background of the disorder, its genetic foundation, and the at the moment to be had and attainable destiny healing brokers. state of the art and extensive ranging, Alzheimer's disorder: equipment and Protocols offers prepared entry to confirmed, reproducible equipment for elucidating the molecular foundation of this most typical senile dementia.

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Extra resources for Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine)

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1998) The ApoE-&4allele and the risk of Alzheimer’s disease among African-Americans, whites and Hispanics. JAMA 279,751-755. 29. Farrer, L. , Cupples, L. , Myers, R. , van Duijn, C. , et al. (1998)Effects of age and ethnicity on the 1inkbetweenApolipopt E genotype and Alzheimer disease: a meta-analysis. JAMA 278,1349-1356. 30. Strittmatter,W. , Saunders,A. , Weisgraber, K. , Dong, L. ,et al. J. Biol. Chem. 270,9039-9042. 31. LaDu, M. , Falduto, M. , Manelli, A. , Reardon, C. , Getz, G. , Frail, D.

Evans, D. , Beckett, L. , Field, T. , Bennett, D. , et al. (1997) Apolipoprotein E &4and incidence of Alzheimer’s disease in a community population of older persons. JAMA 277,822-824. 26. Osuntokun, B. , Ogunniyi, A. , et al. Ann. Neurol. 38,463-465. 27. Hendrie, H. , Hall,K. , Unverzagt, F. ,Yu, C. , et al. ( 1995)Apolipoprotein E genotypes and Alzheimer’s disease in a community stu of elderly African Americans. Ann. 37,118-120. 28. Tang, M. , et al. (1998) The ApoE-&4allele and the risk of Alzheimer’s disease among African-Americans, whites and Hispanics.

Martin, G. , et al. (1996) Increased activity-regulating and neuroprotective efficacy ofa-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain. J. Neurochem. 67, 1882-1894. 90. Hardy, J. and Allsop, D. (1991) Amyloid deposition as the central event in the Trends Phannacol. Sci. 12,383-388. aetiology of Alzheimer’s disease. 91. , Carman, M. , Fernandez-Madrid,I. , Power, M. , van-Duinen, S. , et al. (1990) Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

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Alzheimer's Disease: Methods and Protocols (Methods in Molecular Medicine) by N. M. Hooper

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