By Jay Schulkin
Unlike homeostasis, allostasis refers back to the really new suggestion of "viability via change." This ebook addresses uncomplicated physiological regulatory platforms, and examines physically legislation lower than duress. It integrates the elemental options of physiological homeostasis with problems resembling melancholy, pressure, anxiousness and habit. it's going to curiosity graduate scholars, scientific scholars, and researchers in body structure, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
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Extra info for Allostasis, Homeostasis, and the Costs of Physiological Adaptation
Homeostatic origins of ingestive behavior. In: Neurobiology of Food and Fluid Intake. New York: Plenum Press. , Gault, T. , Fregly, M. J. (1991). Potentiation of angiotensin II-induceddrinking by glucocorticoids is a specific glucocorticoid type II receptor (GR) mediated event. Brain Res 552:283–90. Swanson, L. W. (1999). The neuroanatomy revolution of the 1970s and the hypothalamus. Brain Res Bull 50:397–8. Swanson, L. W. (2003). Brain Architecture. Oxford: Oxford University Press. Sweeny, J. , Seibert, H.
There is a remedy: sense the altered input statististics → calculate a new probability distribution → shift the response curve to rematch its steep region to the most likely loads (Fig. 5, lower panel). This strategy for continually rematching outputs to expected inputs has been observed at all levels of biological organization, from bacteria and somatic (nonneural) cells to neurons (Sakmann and Creutzfeldt, 1969; Koshland, 1987). , 1999). This principle operates at many levels. ” And in the perceptual realm, we identify an ambiguous object by sight or touch by combining sensory inputs with our prior knowledge of what the context suggests is most likely (Geisler and Diehl, 2002, 2003).
Wolf, G. (1964). Sodium appetite elicited by aldosterone. Psychonom Sci 1:211–12. Woods, S. C. (1991). The eating paradox: How we tolerate food. Psychol Rev. 98:588– 505. 1 Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics1,2 Peter Sterling INTRODUCTION This chapter compares two alternative models of physiological regulation. The first model, homeostasis (“stability through constancy”), has dominated physiology and medicine since Claude Bernard declared, “All the vital mechanisms .
Allostasis, Homeostasis, and the Costs of Physiological Adaptation by Jay Schulkin