By G. Ying
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Extra info for Age-Related Macular Degeneration - Recent Advs. in Basic Research, Clin. Care
1997). , 2004). , Pathogenic Roles of Sterile Inflammation in Etiology of Age-Related Macular Degeneration 31 2003). , 2006), further amplifying cellular activation. , 2005). , 2001). , 2004), demonstrating that AGEs are toxic to retinal cells. 2 Carboxyethyl pyrole (CEP) adducts Lipid peroxidation, triggered by direct photobleaching of PUFAs or indirect excitation of photosensitizers contained in RPE lipofuscin, generates a number of reactive dicarbonyl compounds (aldehydes) such as acrolein, 4-hydroxy-2-nonenal (4-HNE), malondialdehyde (MDA) and CEP (Glenn & Stitt, 2009).
Curr Eye Res. 2009 Mar;34(3):238-40. M. (2000). The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 1498, 99111. , et al. (2006). Cigarette smoking strongly modifies the association of LOC387715 and age related macular degeneration. Am J Hum Genet 78, 852-864. Schmidt-Erfurth UM, Elsner H, Terai N, Benecke A, Dahmen G, Michels SM. Effects of verteporfin therapy on central visual field function. Ophthalmology. 2004 May;111(5):931-9. , et al. (2001).
Et al. (2001). Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 158, 1161-1172. Spilsbury K, Garrett KL, Shen WY, Constable IJ, Rakoczy PE. Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization. Am J Pathol. 2000 Jul;157(1):135-44. , and Marshall, J. (1997). Localization of the site of major resistance to fluid transport in Bruch's membrane.
Age-Related Macular Degeneration - Recent Advs. in Basic Research, Clin. Care by G. Ying