By J. F. Goodwin (auth.), Fulvio Camerini, Antonello Gavazzi, Renata De Maria (eds.)
Read Online or Download Advances in Cardiomyopathies: Proceedings of the II Florence Meeting on Advances on Cardiomyopathies April 24–26, 1997 PDF
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Extra info for Advances in Cardiomyopathies: Proceedings of the II Florence Meeting on Advances on Cardiomyopathies April 24–26, 1997
Camici Myocardial Ischemia in Patients with Hypertrophic Cardiomyopathy Chest pain suggestive of reversible myocardial ischemia is a common symptom in patients with hypertrophic cardiomyopathy (HCM) . The ischemic nature of the chest pain, which most often occurs in patients with angiographically normal coronary arteries, could be demonstrated by the presence of reversible perfusion defects on thallium-201 scanning . In addition, net lactate release and a reduced coronary vasodilator reserve during atrial pacing have been reported .
T: ... 0001 20 O~----------~------------r-----------~-----------. o 5 10 15 20 Years Fig. 2. Event-free survival in 330 unselected patients with hypertrophic cardiomyopathy. 05 40 20 0 0 5 10 15 20 Years Fig. 3. Cumulative survival in 330 unselected patients with hypertrophic cardiomyopathy. Kaplan-Meier curve shows increased cardiovascular mortality in 237 symptomatic as compared to 93 asymptomatic patients Discussion A great diversity of morphologic, functional, genetic and clinical expression characterizes patients with HeM [1-8].
While symptoms may occur at any age, myocardial hypertrophy usually develops during periods of rapid somatic growth, sometimes during the first year of life, but more typically during adolescence . De novo myocardial hypertrophy in early middle age is not reported, but idiopathic or "inappropriate" left ventricular hypertrophy in patients over 60 years old is well described [8-10]. While the natural history of HeM is characterised by an age-related progression of symptoms in parallel with gradual deterioration in left ventricular function, less than 10% of patients develop overt congestive cardiac failure .
Advances in Cardiomyopathies: Proceedings of the II Florence Meeting on Advances on Cardiomyopathies April 24–26, 1997 by J. F. Goodwin (auth.), Fulvio Camerini, Antonello Gavazzi, Renata De Maria (eds.)