J. F. Goodwin (auth.), Fulvio Camerini, Antonello Gavazzi,'s Advances in Cardiomyopathies: Proceedings of the II Florence PDF

By J. F. Goodwin (auth.), Fulvio Camerini, Antonello Gavazzi, Renata De Maria (eds.)

ISBN-10: 8847021553

ISBN-13: 9788847021556

ISBN-10: 8847021812

ISBN-13: 9788847021815

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Read Online or Download Advances in Cardiomyopathies: Proceedings of the II Florence Meeting on Advances on Cardiomyopathies April 24–26, 1997 PDF

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Extra info for Advances in Cardiomyopathies: Proceedings of the II Florence Meeting on Advances on Cardiomyopathies April 24–26, 1997

Example text

Camici Myocardial Ischemia in Patients with Hypertrophic Cardiomyopathy Chest pain suggestive of reversible myocardial ischemia is a common symptom in patients with hypertrophic cardiomyopathy (HCM) [1]. The ischemic nature of the chest pain, which most often occurs in patients with angiographically normal coronary arteries, could be demonstrated by the presence of reversible perfusion defects on thallium-201 scanning [2]. In addition, net lactate release and a reduced coronary vasodilator reserve during atrial pacing have been reported [3].

T: ... 0001 20 O~----------~------------r-----------~-----------. o 5 10 15 20 Years Fig. 2. Event-free survival in 330 unselected patients with hypertrophic cardiomyopathy. 05 40 20 0 0 5 10 15 20 Years Fig. 3. Cumulative survival in 330 unselected patients with hypertrophic cardiomyopathy. Kaplan-Meier curve shows increased cardiovascular mortality in 237 symptomatic as compared to 93 asymptomatic patients Discussion A great diversity of morphologic, functional, genetic and clinical expression characterizes patients with HeM [1-8].

While symptoms may occur at any age, myocardial hypertrophy usually develops during periods of rapid somatic growth, sometimes during the first year of life, but more typically during adolescence [7]. De novo myocardial hypertrophy in early middle age is not reported, but idiopathic or "inappropriate" left ventricular hypertrophy in patients over 60 years old is well described [8-10]. While the natural history of HeM is characterised by an age-related progression of symptoms in parallel with gradual deterioration in left ventricular function, less than 10% of patients develop overt congestive cardiac failure [11].

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Advances in Cardiomyopathies: Proceedings of the II Florence Meeting on Advances on Cardiomyopathies April 24–26, 1997 by J. F. Goodwin (auth.), Fulvio Camerini, Antonello Gavazzi, Renata De Maria (eds.)


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