By Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)
A awesome spectrum of novel immunoreceptors sharing comparable immunoglobulin-like domain names and signaling strength has been pointed out lately. those receptors have attracted common curiosity simply because they resemble the TCR, BCR, and FcR complexes of their skill to function activating or inhibitory receptors at the cells that undergo them. furthermore, they're good situated to impact either innate and adaptive immunity. the complete diversity of ligands for those new receptor households remains to be now not recognized, and figuring out in their physiological roles is way from entire. This quantity is the 1st try and summarize and spotlight all identified features of immunoglobulin-like receptors, offering a topical evaluation of the jobs and attribute beneficial properties of the immunoglobulin-like receptors and similar molecules within the immune procedure. Researchers in immunology, molecular biology, phone biology, scientific medication, and pharmacology will locate this e-book invaluable.
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Additional resources for Activating and Inhibitory Immunoglobulin-like Receptors
FeaR, CD89, Promoter, Polymorphism , IgA nephropathy Introduction In human , IgA is the prominent immunoglobulin (Ig) in secretions . One of the protection mechanisms of IgA is implicated in IgA-mediated neutralization and removal of environmental antigens from mucosal sites (Underdown and Schiff 1986). On the other hand, earlier reports describing the Fe receptor for IgA also suggested an active mechanism involving interaction of IgA-immune complexes (IgA-IC) with the specific Fe receptor expressed on effector cells (Fanger et al.
20(0). The apparent function of gp49 molecules should be distinguished from the role of Ly-49 and other MHC class I inhibitory receptors that are thought to act by inhibiting NK cell activation at the time of initial stimulation . These receptors are constitutively and stably expressed on individual NK cells once the mature repertoire is established (Dorfman and Raulet 1998; Valiante et al. 1997) . Perhaps the constitutive and stable expression of such receptors is not surprising since these MHC class l-specific receptors must act immediately to control untoward NK cell activation .
1999), \Wyer et al. 1999), "(Wines et al. 1999), "(van der Merwe et al. 1994), IO(Davis et al. I998b), "(Brown et al. 1998), 12(van der Merwe et al. 1997), 13(Nicholson et al. 1998), "(Tominaga et al. lM) . These affinities are similar to those of many other cell-cell recognition molecules, including TCRIpeptide-MHC interactions (Table 2). However, while the low affinity of TCR/peptide-MHC interactions is a consequence of a relatively slow k"n rather than a fast k"ff (Davis et al. 1998a; Willcox et al.
Activating and Inhibitory Immunoglobulin-like Receptors by Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)