By David O. Cooney
Highlighting activated charcoal's nice effectiveness in treating drug overdoses and poisonings in either people and animals, this complete, single-source reference brings jointly very important info from each major examine at the use of activated charcoal for clinical purposes-describing all to be had charcoal items and their features.
Details activated charcoal's skill to lessen the systemic absorption of an enormous array of substances, chemical substances, and biochemical substances-including analgesics, antipyretics, sedatives, alkaloids, snake venoms, and bacterial and fungal pollutants.
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Extra resources for Activated Charcoal in Medical Applications, Second Edition
These two equations are used more than 99% of the time to describe the equilibrium adsorption of drugs/poisons/toxins to activated charcoal. The reason is simple: in almost every case, one of these two equations fits the data quite well. Thus, there is no need for more elaborate isotherm equations, particularly those involving three or more parameters. A. The Langmuir Isotherm Equation An adsorption "isotherm" equation is an expression of the relation between the amount of solute adsorbed and the concentration of the solute in the fluid phase, at a given constant temperature.
I" ' i ' i 1 ~ ~T 1 1 1 CO £L - | / 0 o> k. o +* ' ^ 1 / -1 o z I n 0 y _^^^ /— ^ \ ■ 2 / I f i 4 ■ i 6 I ■ 8 . I 10 . I . 7 Charge on the salicylate molecule as a function of pH. From Cooney, 1992. 33 Activated Charcoal and the Adsorption Process O 2 4 6 8 10 12 PH Figure 3-8 Adsorption of three aromatic carboxylic acids to activated charcoal as a function of pH. From Cooney and Wijaya (1987). Reproduced by permission of the Engineering Foundation. Chapter 3 34 -£r- ANILINE m-PHENYLENEDIAMINE NhL NH ?
Yet such is not always true. One must be aware that the surface area is usually inferred from the amount of N 2 (a small molecule) which can be adsorbed at -196°C (N2 boiling point). If one wishes to adsorb a large molecule, much of the internal surface area may not be accessible. 5 gives an example of this. 10 g/liter. From Hassler (1963). Reprinted by permission of the Chemical Publishing Company. were initially too small to admit the large molecules of aniline blue finally become large enough to admit them.
Activated Charcoal in Medical Applications, Second Edition by David O. Cooney