By J.K. Aronson (Eds.)
The unwanted side effects of substances Annual is designed to supply a serious and updated account of recent details relating to adversarial drug reactions and interactions from the clinician's standpoint. below the supervision of the sequence editors, a world crew of professional authors have accumulated jointly the newest info on opposed drug results from the overseas literature. as well as describing new studies of inauspicious drug results, the authors have subjected these reviews to serious research, surroundings them into context by way of scientific relevance and significance, and cross-referring to earlier experiences the place important. New opposed results are pronounced and evaluated and formerly stated hostile results are re-evaluated within the gentle of the latest info. a different function is the stories, within which chosen antagonistic results are mentioned intensive. using the e-book is greater by way of separate indexes, permitting the reader to go into the textual content by way of drug identify, adversarial influence identify, or drug interplay. the present Annual is the 1st replace of the normal encyclopaedic paintings during this box, http://www.elsevier.nl/locate/isbn/0444500936Meyler's uncomfortable side effects of substances, Fourteenth version, which was once released in December 2000.
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Extra info for A world-wide survey of new data and trends in adverse drug reactions
D r u g interactions Rizatriptan is a 5HTIB/1D receptor agonist that is metabolized by MAO type A. In 12 young healthy volunteers moclobemide (300 mg/day for 4 days) potentiated the hypertensive effect of acute rizatriptan (10 mg orally) (3c). 3-fold respectively). The authors suggested that moclobemide and rizatriptan should not be given together. TRICYLIC ANTIDEPRESSANTS (SED-14, 44; SEDA-21, 10; SEDA-22, 11; SEDA-23, 16) MONOAMINE OXIDASE INHIBITORS (MAOIs) (SED-14, 37; SEDA-21, 9; SEDA-23, 15) Cardiovascular Conventional irreversible monoamine oxidase inhibitors (MAOIs) are associated with a significant risk of postural hypotension and spontaneous hypertension.
A 27-year-old man developed hepatitis (with raised bilirubin and liver enzymes) without overt jaundice after 12 weeks treatment with nefazodone 200 mg/day (34A). No other cause for the hepatitis could be established and the abnormal liver function tests settled 4 weeks after nefazodone withdrawal They became abnormal again one week after nefazodone rechallenge and settled once again on withdrawal. However, four other female patients, aged 1673 years, developed catastrophic liver failure during nefazodone treatment (35 A, 36A).
A 44-year-old woman developed weakness with abnormal liver function tests (AsT activity of 661 IU/L) about 6 months after starting to take venlafaxine (150 mg/day) (52A). Biopsy showed confluent necrosis in zone 3, with unaffected portal tracts. No other cause for the hepatitis could be found. The clinical and biochemical features resolved within 12 weeks of withdrawal of venlafaxine. Raised liver enzymes have been rarely found in patients taking venlafaxine, and it appears that hepatitis may also be rare adverse effect.
A world-wide survey of new data and trends in adverse drug reactions by J.K. Aronson (Eds.)